Directory and Interactive Maps of Casinos and other Gaming across the Nation including address, hours, phone numbers, and website. Best Casinos in Myrtle Beach, SC 29577 - The Big M Casino (66 reviews). This demand includes Myrtle Beach casinos, in every part of the city and the surrounding areas. Places that they depart from include Little River, North Myrtle, and central Myrtle Beach. A Myrtle Beach gambling cruise involves much more than just hopping on a boat and pulling the handle on a couple of slot machines. Home to South Carolina's only casino ships, the beautiful Atlantic Ocean off the Myrtle Beach area coast comes alive every day and night with Vegas-style gambling, live entertainment and fine food. The area's two casino ships set sail twice on five-hour cruises from beautiful Little River, just a short drive north of Myrtle Beach.